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Pregnant After Macroadenoma Treatment

Hi... Back in December, I was diagnosed with a Macroadenoma which was 4cm in diam.


I began treatment of Cabergoline and have been taking it for 8 weeks now. My prolactin levels went from 468 to less than 30 after my last blood work.

I have yet to have a menstrual cycle and my doc says it may take up to 3 months to return.
My question is, can I become pregnant during this time now that my prolactin is at a normal level?

I feel like i am pregnant and although it would be too early to detect on a pregnancy test, I just wondered if it would even be possible at this point? My husband and I already miscarried a few times years ago and we would love to have an answer to give as some hope of becoming parents again after 16 years:)

Answer :

Yes, it is possible to ovulate and get pregnant once your prolactin levels decrease.

When prolactin levels are high ovulation is inhibited and it is nearly possible to get pregnant with high prolactin levels.
Once prolactin levels decrease, either naturally or under the influence of medication you can get pregnant because ovulation will be stimulated once again.

Prolactin inhibits two hormones necessary to your ovulation: follicle stimulating hormone (FSH) and gonadotropin releasing hormone (GnRH).

These hormones are necessary for the development and maturation of the eggs within the ovary. When prolactin levels are high ovulation is not triggered and your menses will become irregular. You will miss your periods for long periods to time.

Hyperprolactinemia or prolactin levels caused by prolactinoma is a frequent cause of prolactin-induced infertility. It is caused by a benign tumor that grows on the pituitary gland. The presence of this tumor stimulates the production of high levels of prolactin.
Cabergoline has been studied to achieve high pregnancy rates with uneventful outcomes in infertile women with prolactinoma, independent of tumor size and bromocriptine resistance or intolerance. In this study, 85 women with micro and macro-prolactinoma took high-dose of cabergoline therapy for infertility. Some of these patients were either resistant or intolerant to bromocriptine.

The drug was administered for 3 cycles and withdrawn on the fourth. Cabergoline normalized hyperprolactinemia and recovered the ovulatory cycle in all patients. 94% conceived and all the babies were born healthy, without any malformations.

Also, none of the women had vision problems or headache, which may occur during pregnancy, indicating the tumor is increasing in size. (J Clin Endocrinol Metab. 2010 Jun;95(6):2672-9. Epub 2010 Mar 31).

So, you have great possibility of achieving pregnancy like the women in the study. Make sure to take a pregnancy test as soon as possible.

I hope you are finally pregnant!

Many Blessings!

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