Production of Immature Sperm

What causes the production of immature sperm? Is this a sign of epididymitis? Can epididymitis be treated? Can immature sperm (spermatids) be used during the icsi process?

Answer:

The spermatids are immature sperm cells that mature in the epididymis nurtured by the Sertoli cells. It takes about ninety days for the sperm to grow, mature, and finally be collected in the epididymis. Here the sperm become capable of motility.

After each ejaculation, it takes about forty hours for the epididymis to refill with mature sperm. This is why frequent intercourse can impair fertility.

If there is a problem with the epididymis, there is a problem with the sperm motility as the sperm cannot fully mature.

The causes of this can be many:

Hormonal problems

Genetic abnormalities

Damage from drugs, injury, radiation, or excess heat

Adult mumps

Varicocele

Environmental toxins like pesticides

Poor nutrition

Intracytoplasmic sperm injection (ICSI) can be utilized can be used in cases of azoospermia caused either by obstruction of the epididymis or by germinal failure (immature sperm).

Spermatids are immature sperm cells that are not capable of swimming and can still be retrieved and utilized as part of ICSI.

The sperm can be retrieved from:

Epididymis (surgically retrived)

Frozen

Testicular (surgically Retrieved)

Ejaculated

Even non-obstructive azoospermia due to maturation arrest or other impairments in germ cell maturation have been added to the list. In fact, round spermatid or secondary spermatocyte injections are possible.

As long as viable sperm can be retrievable from the male reproductive tract,then IVF-ICSI procedures can be successful.

Epididymitis is due to infection or inflammation of the epididymis.

Bacterial infections are the major sources: gonorrhea, chlamydia and E. coli.

Treatment with antibiotic can usually resolve this type of situation.

I hope this answers your question. Talk to your doctor about your specific case as each man is different.

Many Blessings!

Comments for Production of Immature Sperm

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Appreciation
by: Anonymous

I appreciate your work,your answer for spermtozoa infertility has help in so many ways, thank you, keep on good work.

Answer:

You are very welcome! It is a pleasure to help.

Maria Gioia

EMA
by: Anonymous

My husband was diagnosed with early maturation arrest.. his doctor only found spermatids (heads without tails)... are you saying the head of a sperm without a tail can be used for IVF?

Answer:

If the genetic material is found to be intact, yes.

Studies have the Intracytoplasmic injection (ICSI) of spermatid (not fully developed spermatozoa) into the egg can result in normal fertilization, embryo development and even delivery of live, healthy babies. This is part often vitro fertilization procedure that is used when the male partner has a high number of abnormally shaped spermatozoa, very low sperm count, the sperm has no motility or can' t get alone inside the egg.

Of course each case is unique and requires a careful investigation. Your fertility doctor will be able to tell you if this procedure would work in your case.

Many blessings!


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