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Production of Immature Sperm
What causes the production of immature sperm? Is this a sign of epididymitis? Can epididymitis be treated? Can immature sperm (spermatids) be used during the icsi process?
The spermatids are immature sperm cells that mature in the epididymis nurtured by the Sertoli cells. It takes about ninety days for the sperm to grow, mature, and finally be collected in the epididymis. Here the sperm become capable of motility.
After each ejaculation, it takes about forty hours for the epididymis to refill with mature sperm. This is why frequent intercourse can impair fertility.
If there is a problem with the epididymis, there is a problem with the sperm motility as the sperm cannot fully mature.
The causes of this can be many:
Damage from drugs, injury, radiation, or excess heat
Environmental toxins like pesticides
Intracytoplasmic sperm injection (ICSI) can be utilized can be used in cases of azoospermia caused either by obstruction of the epididymis or by germinal failure (immature sperm).
Spermatids are immature sperm cells that are not capable of swimming and can still be retrieved and utilized as part of ICSI.
The sperm can be retrieved from:
Epididymis (surgically retrived)
Testicular (surgically Retrieved)
Even non-obstructive azoospermia due to maturation arrest or other impairments in germ cell maturation have been added to the list. In fact, round spermatid or secondary spermatocyte injections are possible.
As long as viable sperm can be retrievable from the male reproductive tract,then IVF-ICSI procedures can be successful.
Epididymitis is due to infection or inflammation of the epididymis.
Bacterial infections are the major sources: gonorrhea, chlamydia and E. coli.
Treatment with antibiotic can usually resolve this type of situation.
I hope this answers your question. Talk to your doctor about your specific case as each man is different.
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