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METHOTREXATE Medication And Egg Retrieval

by Laura
(Virginia, USA)

I am taking METHOTREXATE medication. My husband and I are planning on using a surrogate to have a baby.

Do I have to get off METHOTREXATE to extract my eggs for the in vitro? Or can I continue taking the medication.

Thank you


Hi Laura,

Methotrexate is a highly toxic anticancer drug that is also an anti-metabolite. It is used to treat a wide range of medical conditions, so I am not sure why you are taking it.

It is used to attack abnormal tissue growth. Sometimes used to treat ectopic and molar pregnancies.

There is limited information on egg quality after taking Methotrexate. Since the medication works on dividing cells and a woman’s eggs do not divide until they are fertilized, future pregnancies should not be affected.

You really need to discuss this with your doctor, but the common protocol is to stop taking Methotrexate and wait three months before starting IVF cycle.

In some instances taking low dosage Methotrexate after ectopic pregnancy may require less time before doing another IVF cycle with egg retrieval.

Each case needs to be individually evaluated by your reproductive endocrinologist.

Many Blessings!

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